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Conclusion: A candidate gene score based on 19 Tier1 variants showed significant association with fibrosis and MAS in a large cohort of patients with biopsy proven MASLD

They inferred that HCO 4 , the oxidizing species, is formed by reaction between H 2 O 2 and CO 2 within the enzyme, enabling it to quickly oxidize the key thiol and redirect carbon flux from glycolysis to the NADPH-generating pentose-phosphate pathway (Winterbourn et al., 2023)